For centuries, spectrometers have been one of the research focuses of the scientific community because of their advantages such as high accuracy, large measurement range, fast speed and small sample usage. However, "large size, high cost, and need for professional operation" have always been the most difficult difficulties to overcome in the development of spectrometers.

In the past two decades, Professor Ke Zhenghao has led a research team to not only miniaturize laboratory-sized spectral detection equipment into a "spectrochip" the size of an SD card, but also successfully shrink the spectrometer to the size of a palm. Can be carried with you and tested at any time. In the future, we will build a health care network connecting home and hospital through cooperation with professional medical institutions to realize telemedicine, precision medicine, AI smart medicine and preventive medicine.

"Any scientific research must first undergo repeated theoretical calculations and verifications before it can step into the research and development process of technology and equipment." Theoretical construction alone is an "impossible task."

The research team led by Professor Ke used groundbreaking innovative technology to manufacture spectral chips using a wafer production method, which not only successfully reduced the size of the spectrometer to a significant extent, but also made it portable. It has a wide range of applications and does not require professional personnel. You can do the test yourself anytime and anywhere. The test results will also be uploaded to a cloud database. By integrating with professional medical institutions, a health care network connecting home and hospital can be built to achieve telemedicine and preventive medicine.

The "Shenguan Precision Rapid Screening Device" developed by the team has been used by many hospitals for rapid quantitative antibody screening, and the antibody detection sensitivity of the Shenguan Rapid Screening Device has been confirmed in clinical trials in many medical institutions. It is actually more than a thousand times the international standard ELISA (Enzyme-Linked Immunosorbent Assay). It is a groundbreaking new technology with the uniqueness and superiority of early trace detection of antibodies.

The SG rapid screening device supports Taipei City's rapid antibody screening research. How does it achieve the four major advantages of being fast, economical, accurate, and extensive?

The "Shenguan Precision Rapid Screening Device" currently supports 5,000 antibody rapid screening studies at Wanhua Hospital in Taipei City, giving full play to its advantages of "fast, economical, accurate and wide". "Fast": The entire antibody test process is completed within 15 minutes (compared to the hospital's machine, which takes more than two hours to process and test samples); "Economic": Only one drop of blood is required, and no sample is required Pre-processing; "Accurate": the accuracy is the same as that of the machine in the hospital; "Wide": the machine is small in size and can be used to set up testing points widely. Moreover, the data can be uploaded to the cloud instantly for real-time big data analysis of epidemic investigation.

It only takes 10,000 "Shenguan Precision Rapid Screening Devices" to be widely distributed throughout Taipei City, and it will take 5 days to complete the precise rapid antibody screening of all citizens of Taipei City. Testing points can be widely set up in clinics, health stations and other places, so that antibody testing can be "decentralized" and there is no need to go back to the hospital for testing, which can greatly reduce the current burden on hospitals.

It is expected to assist in the decentralization of testing

The "Shenguan Precision Rapid Screening Instrument" can accurately detect the concentration of neutralizing antibodies in the human body. Detecting the concentration of neutralizing antibodies can accurately measure the protective power of the vaccine. Professor Ke’s team is working with the FDA CLIA laboratory at Temple University in the United States to conduct precise and rapid screening of neutralizing antibodies. So far, clinical trials involving 400 people have been completed, with a 98% consistency with the large-scale comparison. We are currently preparing to apply for EUA (emergency authorization) from the FDA (U.S. Food and Drug Administration).

If approved, the "Shenguang Precision Rapid Screening Device" will be the world's first POCT (Point-of-Care Testing, which means that medical diagnostic tests are performed at the time and place of patient care, such as at the bedside, at the clinic, or at the hospital). The neutralizing antibody precision detector can be widely used in personal doctor consultations, clinics and other places. After EUA is passed in the future, 600,000 clinics across the United States will become the market for the "Shenguan Precision Rapid Screening Device", which can fully realize the ideal of "decentralized testing".

The "Shenguan Precision Rapid Screening Device" developed using the spectral chip has many innovative advantages and has been recognized by medical experts and won international and national awards:

(1) 2021 International Innovation Award (IIA)

(2) 2021 National Innovation Award and Future Technology Breakthrough Award

(3) Won three National Innovation Awards in 2020 (the only time in the history of the National Innovation Awards that the same technology won three awards in the same year)

(4) Won the "Future Technology Breakthrough Award" of the Ministry of Science and Technology for two consecutive years in 2018 and 2019 (the only technology in the history of the Future Technology Breakthrough Award to win two consecutive years).

The detection platform of the spectrum chip is based on the concept of a universal machine: everything has a spectrum. In the future, it can be applied to blood, tumors, various chronic diseases, urine, pet urine, and even food safety, plasticizers, industrial heavy metals, semiconductor factory pollution, etc., and after combining AI intelligent big data operation and analysis, it can achieve long-term End-to-end charging, telemedicine, remote long-term care monitoring, and precision medicine.